Warfarin Interactions With Antibiotics

Posted by TL on Feb 2, 2014 in POEMs | 0 comments

Warfarin Interactions With Antibiotics in the Ambulatory Care Setting [JAMA Intern Med. 2014]

A retrospective, longitudinal cohort study evaluated patients receiving warfarin between January 1, 2005, and March 31, 2011, at Kaiser Permanente Colorado.

CONCLUSIONS AND RELEVANCE

Acute upper respiratory tract infection increases the risk of excessive anticoagulation independent of antibiotic use.

Antibiotics also increase the risk; however, most patients with previously stable warfarin therapy will not experience clinically relevant increases in INR following antibiotic exposure or acute upper respiratory tract infection.