Oral or transdermal opioids for osteoarthritis of the knee or hip?

Oral or transdermal opioids for osteoarthritis of the knee or hip. [Cochrane Database Syst Rev. 2014] – PubMed – NCBI

Bugger. The benefits of opioids in osteoarthritis are probably outweighed by the negatives.

The small mean benefit of non-tramadol opioids are contrasted by significant increases in the risk of adverse events. For the pain outcome in particular, observed effects were of questionable clinical relevance since the 95% CI did not include the minimal clinically important difference of 0.37 SMDs, which corresponds to 0.9 cm on a 10-cm VAS.

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